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副高级专业技术人员

李鹏伟副研究员

李鹏伟副研究员

李鹏伟 副研究员

博士、主任助理、硕士生导师

研究方向：微生物天然产物生物合成及药物开发
+86（10）64806118
lipw@im.ac.cn
北京市朝阳区北辰西路1号院3号

研究方向

微生物天然产物生物合成及药物开发

教育经历

  • 2005.9-2009.7 兰州交通大学 本科
  • 2009.9-2012.7 山东大学 硕士
  • 2012.9-2016.7 中国科学院微生物研究所 博士

工作经历

  • 2016-2020 中国科学院微生物研究所，助理研究员
  • 2020-至今 中国科学院微生物研究所，副研究员

获奖及荣誉

2023年入选中国科学院青年创新促进会

社会兼职

  • Frontiers in Microbiology编委
  • 《微生物学报》青年编委
  • 《微生物学通报》青年编委
Oxidative cleavage of hexopyranose by a TIM-barrel isomerase

Oxidative cleavage of hexopyranose by a TIM-barrel isomerase

Pengwei Li#, Dacheng Wang#, Yihua Chen*, et al.

Nature Catalysis 2025
我国科研团队在酶催化研究领域取得新突破
2025年10月3日

我国科研团队在酶催化研究领域取得新突破

新华社北京10月3日电（记者胡喆、顾天成）记者从中国科学院获悉，中国科学院微生物研究所陈义华团队、李德峰团队联合厦门大学王斌举团队，发现一种金属异构酶具有催化己糖氧化裂解的新功能...

阅读更多

近年代表性研究论文

(#共同第一，*通讯作者)

Oxidative cleavage of hexopyranose by a TIM-barrel isomerase

Li Pengwei; Wang, Dacheng; Guo, Lu; Chen, Yanru; Mao, Huijin; Zhao, Zelian; Wang, Min; Chen, Meng; Xu, Zhengren; Wang, Binju; Li, Defeng; Chen, Yihua

Nature Catalysis 2025, 8 DOI: 10.1038/s41929-025-01412-8

Reprogramming of the Aurantinin Polyketide Assembly Line to Synthesize Auritriacids by Excising an Atypical Enoyl-CoA Hydratase Domain

Wang Dacheng; Mao, Huijin; Zhao, Zelian; Liu, Lilu; Chen, Yihua; Li, Pengwei

Advanced Science 2024, 11 DOI: 10.1002/advs.202401708
Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly

Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly

Liu Lilu; Wang, Wenzhao; Chen, Meng; Zhang, Yuwei; Mao Huijin; Wang Dacheng; Chen Yihua; Li Pengwei

Appl Microbiol Biotechnol 2023, 107, 2403-2412 DOI: 10.1007/s00253-023-12481-9
(S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue pigment indigoidine

(S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue pigment indigoidine

Zhang Zhilong, Li Pengwei, Wang Min, Zhang Yan, Wu Bian, Tao Yong, Pan Guohui & Chen Yihua

mLife 2022, 1, 146-155 DOI: 10.1002/mlf2.12023
Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome

Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome

Zhang Yuwei, Li Pengwei, Ma Yue, Wang Jun & Chen Yihua

Clinical and Translational Medicine 2022, 12, e1011 DOI: 10.1002/ctm2.1011
Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations

Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations

Wang Dacheng, Li Pengwei, Yan Jia-Lei, Mao Huijin, Liu Lilu, Wang Min, Chen Meng, Ye Tao & Chen Yihua

Organic Chemistry Frontiers 2022, 9, 5949-5954 DOI: 10.1039/D2QO01251K
Initiating polyketide biosynthesis by on-line methyl esterification

Initiating polyketide biosynthesis by on-line methyl esterification

Li Pengwei, Chen Meng, Tang Wei, Guo Zhengyan, Zhang Yuwei, Wang Min, Horsman Geoff P., Zhong Jin, Lu Zhaoxin & Chen Yihua

Nature Communications 2021, 12 DOI: 10.1038/s41467-021-24846-7
Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis

Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis

Tang Wei, Li Pengwei, Chen Meng, Guo Zhengyan & Chen Yihua

Organic Letters 2020, 22, 5251-5254 DOI: 10.1021/acs.orglett.0c01918
Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy

Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy

Li Pengwei, Guo Zhengyan, Tang Wei & Chen Yihua

Synthetic and Systems Biotechnology 2018, 3, 254-260 DOI: 10.1016/j.synbio.2018.10.010
Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling

Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling

Guo Zhengyan, Li Pengwei, Chen Guozhu, Li Chao, Cao Zhenju, Zhang Yuwei, Ren Jinwei, Xiang Hua, Lin Shuangjun, Ju Jianhua & Chen Yihua

Journal of the American Chemical Society 2018, 140, 18009-18015 DOI: 10.1021/jacs.8b10136
An efficient blue-white screening based gene inactivation system for Streptomyces

An efficient blue-white screening based gene inactivation system for Streptomyces

Li Pengwei; Li, Jine; Guo, Zhengyan; Tang, Wei; Han, Jianshan; Meng, Xiangxi; Hao, Tingting; Zhu, Yaxin; Zhang, Lixin; Chen, Yihua

Applied Microbiology and Biotechnology 2015, 99, 1923-1933 DOI: 10.1007/s00253-014-6369-0