全部论文 | 微生物代谢与生命健康研究组

Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity

Zhang Yuwei; Zong, Jianfa; Liu, Yufeng; Zhou, Keyu; Shi, Haibo; Yin, Wen-Bing; Liu, Ling; Chen, Yihua

Natural Product Reports 2025

Oxidative cleavage of hexopyranose by a TIM-barrel isomerase

Li Pengwei; Wang, Dacheng; Guo, Lu; Chen, Yanru; Mao, Huijin; Zhao, Zelian; Wang, Min; Chen, Meng; Xu, Zhengren; Wang, Binju; Li, Defeng; Chen, Yihua

Nature Catalysis 2025

Selective Synthesis of Cyclopeptides with a 2-Oxindole or 3a-Hydroxy-hexahydropyrrolo-[2,3-b]indole Structure by Cytochrome P450 Enzymes

Li Chao; Ma, Junying; Guo, Lu; Xu, Chao; Zhong, Zijian; Li, Pengwei; Tang, Yue; Wang, Wenzhao; Li, Defeng; Ye, Tao; Guo, Zhengyan; Chen, Yihua

Journal of the American Chemical Society 2025

Reprogramming of the Aurantinin Polyketide Assembly Line to Synthesize Auritriacids by Excising an Atypical Enoyl-CoA Hydratase Domain

Wang Dacheng; Mao, Huijin; Zhao, Zelian; Liu, Lilu; Chen, Yihua; Li, Pengwei

Advanced Science 2024

NDP-β-d-manno-heptoses are small molecule agonists sensed by the vertebrates to discriminate organisms of different kingdoms

Tang Yue; Zhong, Zijian; Mao, Huijin; Chen, Yihua

Clinical and Translational Medicine 2024

The β-d-manno-heptoses are immune agonists across kingdoms

Tang Yue; Tian, Xiaoying; Wang, Min; Cui, Yinglu; She, Yang; Shi, Zhaoxiang; Liu, Jiaqi; Mao, Huijin; Liu, Lilu; Li, Chao; Zhang, Yuwei; Li, Pengwei; Ma, Yue; Sun, Jinyuan; Du, Qing; Li, Jie; Wang, Jun; Li, De-feng; Wu, Bian; Shao, Feng; Chen, Yihua

Science 2024

Characterization of the ADP-β-d-manno-heptose biosynthetic enzymes from two pathogenic Vibrio strains

Shi Zhaoxiang; Tang, Yue; Wang, Zhenyi; Wang, Min; Zhong, Zijian; Jia, Jingming; Chen, Yihua

Applied Microbiology and Biotechnology 2024

NeoI represents a group of transcriptional repressors regulating the biosynthesis of multiple aminoglycosides

Li Yue; Meng, Xiangxi; Li, Dong; Xia, Xiulei; Zhang, Jihui; Chen, Yihua; Tan, Huarong

Science China-Life Sciences 2024

Production improvement of an antioxidant in cariogenic Streptococcus mutans UA140

Li Shuyu; Zhang, Yuwei; Zong, Jianfa; Liu, Yufeng; Tang, Yue; Lu, Jincai; Chen, Yihua

Journal of Applied Microbiology 2024

Reconstitution of Septacidin Biosynthesis in Escherichia coli by Redirecting an ADP-Heptose Precursor from Primary Metabolism

Chen Meng; Wang, Min; Shi, Zhaoxiang; Li, Pengwei; Zhang, Yuwei; Li, Zilong; Wang, Weishan; Tang, Yue; Chen, Yihua

ACS Sustainable Chemistry & Engineering 2024

Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation

Zhang Yuwei; Liao, Ge; Wang, Min; Zhang, Zhao; Liu, Liwei; Song, Yuqin; Wang, Dacheng; Hao, Tingting; Feng, Jie; Xia, Bin; Wang, Yixiang; Tang, Xiaoyu; Chen, Yihua

Microbiome 2023

Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly

Liu Lilu; Wang, Wenzhao; Chen, Meng; Zhang, Yuwei; Mao Huijin; Wang Dacheng; Chen Yihua; Li Pengwei

Appl Microbiol Biotechnol 2023

Engineering the C3N Pathway as a Short Detour for De Novo NAD+ Biosynthesis in Saccharomyces cerevisiae

Li Xinli, Tang Yue, Ding Yong, Li Pengwei & Chen Yihua

Fermentation 2023

Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase

Chen Meng; Guo, Zhengyan; Sun, Jinyuan; Tang, Wei; Wang, Min; Tang, Yue; Li, Pengwei; Wu, Bian; Chen, Yihua

Acta Pharm Sin B 2023

人体微生物天然产物研究进展

张雨薇, 刘煜峰 & 陈义华

药学进展 2023

(S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue pigment indigoidine

Zhang Zhilong, Li Pengwei, Wang Min, Zhang Yan, Wu Bian, Tao Yong, Pan Guohui & Chen Yihua

mLife 2022

Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome

Zhang Yuwei, Li Pengwei, Ma Yue, Wang Jun & Chen Yihua

Clinical and Translational Medicine 2022

Construction and heterologous expression of the di-AFN A(1) biosynthetic gene cluster in Streptomyces model strains

Yihua Wei Weijia; Wang Wenzhao; Li Chao; Tang Yue; Guo Zhengyan; Chen

Chin J Nat Med 2022

Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations

Wang Dacheng, Li Pengwei, Yan Jia-Lei, Mao Huijin, Liu Lilu, Wang Min, Chen Meng, Ye Tao & Chen Yihua

Organic Chemistry Frontiers 2022

A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria

Tang Yue, Tang Wei, Wang Min, Zhang Zhilong & Chen Yihua

Science China-Life Sciences 2022

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Ma Yue; Guo, Zhengyan; Xia, Binbin; Zhang, Yuwei; Liu, Xiaolin; Yu, Ying; Tang, Na; Tong, Xiaomei; Wang, Min; Ye, Xin; Feng, Jie; Chen, Yihua; Wang, Jun

Nat Biotechnol 2022

Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597

Chen Meng, Cao Zhenju, Tang Wei, Wang Min, Chen Yihua & Guo Zhengyan

Journal of Antibiotics 2022

Initiating polyketide biosynthesis by on-line methyl esterification

Li Pengwei, Chen Meng, Tang Wei, Guo Zhengyan, Zhang Yuwei, Wang Min, Horsman Geoff P., Zhong Jin, Lu Zhaoxin & Chen Yihua

Nature Communications 2021

Discovery of Brominated Alboflavusins With Anti-MRSA Activities

Li Chao, Bao Wuyundalai, Zhang Haoyue, Lyu Zhitang, Chen Yihua & Guo Zhengyan

Frontiers in Microbiology 2021

Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses

Guo Zhengyan, Tang Yue, Tang Wei & Chen Yihua

Natural Product Reports 2021

Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis

Ding Yong, Wang Min, Li Jine, Li Pengwei, Guo Zhenyan & Chen Yihua

Biochemical and Biophysical Research Communications 2021

Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway

Ding Yong, Li Xinli, Horsman Geoff P., Li Pengwei, Wang Min, Li Jine, Zhang Zhilong, Liu Weifeng, Wu Bian, Tao Yong & Chen Yihua

Advanced Science 2021

应用响应面法优化发酵培养基提高达托霉素产量

张昊月, 郭正彦, 吕志堂 & 陈义华

微生物学通报 2021

Activation of paulomycin production by exogenous gamma-butyrolactone signaling molecules in Streptomyces albidoflavus J1074

Zhang Yuwei; Wang, Min; Tian, Jun; Liu, Jia; Guo, Zhengyan; Tang, Wei; Chen, Yihua

Applied Microbiology and Biotechnology 2020

Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage

Wang Min, Xie Zhoujie, Tang Shoubin, Chang Ee Ling, Tang Yue, Guo Zhengyan, Cui Yinglu, Wu Bian, Ye Tao & Chen Yihua

Organic Letters 2020

Deciphering the Biosynthesis of TDP-beta-L-oleandrose in Avermectin

Tang Yue, Wang Min, Qin Hua, An Xiangxiang, Guo Zhengyan, Zhu Guoliang, Zhang Lixin & Chen Yihua

Journal of Natural Products 2020

Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis

Tang Wei, Li Pengwei, Chen Meng, Guo Zhengyan & Chen Yihua

Organic Letters 2020

Cloning and Expression of a Nonribosomal Peptide Synthetase to Generate Blue Rose

Urs Ankanahalli N. Nanjaraj, Hu Yiling, Li Pengwei, Yuchi Zhiguang, Chen Yihua & Zhang Yan

ACS Synth Biol 2019

An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

Hao Tingting, Xie Zhoujie, Wang Min, Liu Liwei, Zhang Yuwei, Wang Weicang, Zhang Zhao, Zhao Xuejin, Li Pengwei, Guo Zhengyan, Gao Shushan, Lou Chunbo, Zhang Guodong, Merritt Justin, Horsman Geoff P. & Chen Yihua

Nature Communications 2019

L-六碳糖形成机制的研究进展

陈萌, 唐伟, 郭正彦 & 陈义华

微生物学通报 2019

D-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B

Tang Wei, Guo Zhengyan, Cao Zhenju, Wang Min, Li Pengwei, Meng Xiangxi, Zhao Xuejin, Xie Zhoujie, Wang Wenzhao, Zhou Aihua, Lou Chunbo & Chen Yihua

Proceedings of the National Academy of Sciences of the United States of America 2018

Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy

Li Pengwei, Guo Zhengyan, Tang Wei & Chen Yihua

Synthetic and Systems Biotechnology 2018

Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling

Guo Zhengyan, Li Pengwei, Chen Guozhu, Li Chao, Cao Zhenju, Zhang Yuwei, Ren Jinwei, Xiang Hua, Lin Shuangjun, Ju Jianhua & Chen Yihua

Journal of the American Chemical Society 2018

Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp and Their Antioxidant Effects

Gao Chunzhi, Guo Zhengyan, Lu Xingzhong, Chen Haiyan, Liu Liwei, Yu Zhiguo & Chen Yihua

Journal of Natural Products 2018

通过保罗酸的加成提高保罗霉素的稳定性

唐越, 王敏, 丁勇, 李金娥 & 陈义华

有机化学 2018

Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387

Meng Xiangxi, Wang Wenzhao, Xie Zhoujie, Li Pengwei, Li Yue, Guo Zhengyan, Lu Yingjian, Yang Jie, Guan Kaile, Lu Zhaoxin, Tan Huarong & Chen Yihua

Science China-Life Sciences 2017

新结构硫脲类化合物的合成、鉴定及抑菌活性评价

张志国, 唐越, 王敏 & 陈义华

微生物学通报 2017

变形链球菌中的次级代谢产物及其在口腔生物被膜中的生态功能

谢周杰, 张昭, 刘力伟, 柳孝晨 & 陈义华

生物工程学报 2017

Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp CGMCC 4.7309 by genome mining

Tian Jun; Chen, Haiyan; Guo, Zhengyan; Liu, Ning; Li, Jine; Huang, Ying; Xiang, Wensheng; Chen, Yihua

Applied Microbiology and Biotechnology 2016

Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans

Liu Liwei, Hao Tingting, Xie Zhoujie, Horsman Geoff P. & Chen Yihua

Scientific Reports 2016

Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins

Li Jine, Wang Min, Ding Yong, Tang Yue, Zhang Zhiguo & Chen Yihua

Scientific Reports 2016

链丝菌素类抗生素的研究进展

李金娥, 王敏 & 陈义华

微生物学报 2016

An efficient blue-white screening based gene inactivation system for Streptomyces

Li Pengwei; Li, Jine; Guo, Zhengyan; Tang, Wei; Han, Jianshan; Meng, Xiangxi; Hao, Tingting; Zhu, Yaxin; Zhang, Lixin; Chen, Yihua

Applied Microbiology and Biotechnology 2015

Identification and Analysis of the Paulomycin Biosynthetic Gene Cluster and Titer Improvement of the Paulomycins in Streptomyces paulus NRRL 8115

Li Jine, Xie Zhoujie, Wang Min, Ai Guomin & Chen Yihua

PLoS One 2015

Biosynthesis of the carbamoylated D-gulosamine moiety of streptothricins: involvement of a guanidino-N-glycosyltransferase and an N-acetyl-D-gulosamine deacetylase

Guo Zhengyan, Li Jine, Qin Hua, Wang Min, Lv Xun, Li Xuebing & Chen Yihua

Angew Chem Int Ed Engl 2015

Isolation of an anthrabenzoxocinone 1.264-C from Streptomyces sp FXJ1.264 and absolute configuration determination of the anthrabenzoxocinones

Chen Haiyan, Liu Ning, Huang Ying & Chen Yihua

Tetrahedron-Asymmetry 2014

Mining of a streptothricin gene cluster from Streptomyces sp TP-A0356 genome via heterologous expression

Li Jine, Guo ZhengYan, Huang Wei, Meng XiangXi, Ai GuoMin, Tang GongLi & Chen YiHua

Science China-Life Sciences 2013